HEMATOPOIESIS AND STEM CELLS miR-21 mediates hematopoietic suppression in MDS by activating TGF-b signaling
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چکیده
miR-21 mediates hematopoietic suppression in MDS by activating TGF-b signaling Tushar D. Bhagat, Li Zhou, Lubomir Sokol, Rachel Kessel, Gisela Caceres, Krishna Gundabolu, Roni Tamari, Shanisha Gordon, Ioannis Mantzaris, Tomasz Jodlowski, Yiting Yu, Xiaohong Jing, Rahul Polineni, Kavi Bhatia, Andrea Pellagatti, Jacqueline Boultwood, Suman Kambhampati, Ulrich Steidl, Cy Stein, Wenjun Ju, Gang Liu, Paraic Kenny, Alan List, Markus Bitzer, and Amit Verma
منابع مشابه
Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase.
Even though myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis, the molecular alterations that lead to marrow failure have not been well elucidated. We have previously shown that the myelosuppressive TGF-β pathway is constitutively activated in MDS progenitors. Because there is conflicting data about upregulation of extracellular TGF-β levels in MDS, we wanted to det...
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TRAF-interacting protein with forkhead-associated domain B (TIFAB) is a haploinsufficient gene in del(5q) myelodysplastic syndrome (MDS). Deletion of Tifab results in progressive bone marrow (BM) and blood defects, including skewed hematopoietic stem/progenitor cell (HSPC) proportions and altered myeloid differentiation. A subset of mice transplanted with Tifab knockout (KO) HSPCs develop a BM ...
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